Allobarbital

Allobarbital
Systematic (IUPAC) name
5,5-diprop-2-enyl-1,3-diazinane-2,4,6-trione
Identifiers
CAS number	52-43-7
ATC code	N05CA21
PubChem	5842
Chemical data
Formula	C10H12N2O3
Mol. mass	208.214 g/mol
SMILES	eMolecules & PubChem
Synonyms	5,5-Diallylbarbituric acid, Allobarbital
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Allobarbital is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant Chocholova L, Radil-Weiss T. Effect of allobarbital on focal epilepsy in rats. Physiologia Bohemoslovaca. 1971;20(4):325-34. although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia, Getova D, Georgiev V. GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists. Acta Physiologica et Pharmacologica Bulgarica. 1987;13(3):43-50. and is still used in some countries in Asia, Africa and the Middle East.

References

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